WP5

Fishmed visibility

IIMCB is currently involved in numerous promotional, dissemination, and popularisation activities. Our web page presents all important and up-to-date information and events related to IIMCB activities. Other public relations actions during conferences, workshops, kick-off meetings, and awards ceremonies are carried out by our staff. In addition to the promotion of research, we support the popularisation of molecular and cell biology in society. This is organised by the Centre for Innovative Bioscience Education (BioCEN), which since 2003, runs workshops with hands-on experiments in a dedicated laboratory located in IIMCB. IIMCB also supports patient organisations. In 2005, one of our staff members organised the patient association J-elita, bringing together the families of patients who suffer from Crohn’s disease and Colitis (J-elita’s office is located on the IIMCB premises).A recently established Polish Society of Primary Ciliary Dyskinesia was organised by our employee.

All of these activities performed by IIMCB personnel from various units need professional coordination, leadership, and adjustments to rapidly developing needs. We plan to extend them by creating an interactive visibility platform, a set of integrated activities that focus on the popularisation of the FishMed Centre and research on zebrafish models among scientific and non-scientific communities, and promoting the project results for commercialisation purposes. The implementation of this initiative is coordinated by specifically designated personnel, including a public relations specialis. The visibility platform will focus on three main tasks. First, it will develop cooperation with relevant target groups from outside academia, such as patient organisations, local authorities, and the general public. This initiative will allow for the better identification of societal and market needs, sensitise public authorities to the importance of health research, and increase social awareness and enthusiasm for research activities. Second, it will create a discussion forum for the Polish scientific community on the usage of zebrafish models for studies of human diseases as an alternative to mammalian models. We will introduce the concept of zebrafish research to the local scientific community, become a local source of information, and create discussion, knowledge, and intellectual exchange forums on new research models. Third, it will disseminate the scientific results of the FishMed Centre through publications, lectures, and posters.


 6th EUROPEAN FORUM FOR MARKETING OF SCIENTIFIC AND RESEARCH ORGANIZATIONS

On November 19-20, 2015 Daria Goś participated in the 6th European Forum For Marketing Of Scientific And Research Organizations, Warsaw, Poland. Daria Goś presented a poster entitled “Be Healthy as a Fish educational program at the International Institute of Molecular and Cell Biology in Warsaw”. Furthermore, the forum was an occasion to discuss and exchange views in the field of marketing of scientific and research organizations.

9th ZEBRAFISH MEETING

Daria Filipek participated in the 9th Zebrafish Meeting in Oslo, Norway. Daria Filipek gave a presentation entitled “Be Healthy as a Fish educational campaign” at the workshop “Zebrafish in Teaching”. Furthermore, the conference was an opportunity to promote FishMed project and distribute brochures about IIMCB.


REGULATION OF WAKE ACTIVE NEURONS IN ZEBRAFISH, DANIO RERIO

On March 26, 2015 International Institute of Molecular and Cell Biology was visited by Maria Sundvik, PhD, Neuroscience Center, Institute of Biomedicine, Anatomy University of Helsinki, Finland. Maria Sundvik held a seminar entitled “Regulation of wake active neurons in zebrafish, Danio rerio“. Maria Sundvik was hosted by Prof. Jacek Kuźnicki.


ZEBRAFISH AS A MODEL OF CANCER

On September 8, 2014 International Institute of Molecular and Cell Biology was visited by Marina Mione, M.D., Ph.D., Karlsruhe Institute of Technology (KIT), Germany. Marina Mione held a seminar entitled ”Zebrafish as a model of cancer”. Marina Mione was hosted by Cecilia L. Winata.


A DUAL ROLE OF ESCRT PROTEINS IN
THE FORMATION AND FUNCTION OF CILIATED ORGANS

On April 10, 2014 International Institute of Molecular and Cell Biology was visited by Dr. Maximilian Fürthauer, Valrose Institute of Biology, Nice, France. Dr. Fürthauer held a seminar entitled ”A dual role of ESCRT proteins in the formation and function of ciliated organs”. Dr. Maximilian Fürthauer was hosted by Prof. Marta Miączyńska.


EXPERIENCE OF THE REGPOT-PL PROJECTS
IN IMPROVING COMPETENCE IN
THE FUTURE EC PROJECTS’ MANAGEMENT

On March 27, 2014 Dr. Urszula Białek- Wyrzykowska, FishMed Project Manager participated  in the mini-symposium Experience of the REGPOT-PL projects in improving  competence in the future EC projects’ management. Dr. Wyrzykowska delivered a presentation entitled ‘’FishMed – from basic research to innovation’’. The mini-symposium Experience of the REGPOT-PL projects in improving  competence in the future EC projects’ management was organized by Warsaw University of Life Sciences (SGGW) as a part of the Warsaw Plant Health Initiative. The main objective of this event was to integrate research teams from different institutions through the exchange of experiences related to the preparation and implementation of EU projects at universities and research institutes.


WNT NON-CANONICAL SIGNALING PATTERNS
CARDIAC FORM AND FUNCTION

On February 6, 2014 International Institute of Molecular and Cell Biology was visited by Daniela Panakova, PhD, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany. Daniela Panakova held a seminar entitled ”Wnt non-canonical signaling patterns cardiac form and function”.


REGENERATION IN PLANARIA:
WHY SOME CAN WHILE OTHERS CAN’T

On January 23, 2014 International Institute of Molecular and Cell Biology was visited by Johen C. Rink, PhD, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany. Johen C. Rink held a seminar entitled ”Regeneration in Planaria: Why some can while others can’t”. Johen C. Rink was hosted by Prof. Marta Miączyńska.


The H2020-TEERA 2013 CONFERENCE

On October 17–18, 2013 Prof. Jacek Kuźnicki, Director of the International Institute of Molecular and Cell Biology, participated in the conference The EU HORIZON 2020 Programme and Teaming for Excellence in the European Research Area, Prague, Czech Republic. In presentation entitled ‘’Pathways of newly established international infrastructure (IIMCB) to European excellence’’ Prof. Kuźnicki presented the milestones in IIMCB’s development , including FishMed project. The conference, organized in cooperation with the Max Planck Society, launched the HORIZON 2020 programme in the Czech Republic with special focus on teaming of excellent research institutions and those from less performing regions. Horizon 2020 has ambitious goals. Running from 2014 to 2020 with an €70 billion budget, the EU’s new program for research and innovation shall secure Europe’s global competitiveness, new growth and jobs in Europe. It shall provide a boost to top-level research in Europe, strengthen industrial leadership in innovation and address major societal challenges such as demographic change and health, food security and sustainable agriculture and bio-economy, secure and clean and efficient energy, smart and integrated transport, climate action and resource efficiency, inclusive and innovative and secure societies etc. Through FishMed project IIMCB researches will have better chances to participate successfully in Horizon2020.

Programme of The EU Horizon 2020 Programme and Teaming for Excellence in the European Research Area Conference 2013 (H2020 – TEERA 2013) is available here.


CILIOGENESIS AND CELL POLARITY IN THE VERTEBRATE EMBRYO

On October 9-11, 2013 International Institute of Molecular and Cell Biology was visited by Prof. Jarema Malicki, University of Sheffield, UK. Prof. Jarema Malicki held a seminar entitled “Ciliogenesis and cell polarity in the vertebrate embryo”. Prof. Malicki is a world class expert in zebrafish research and his talk regarding genetics of cilia function was an important source of novel information and inspiration to IIMCB FishMed employees. During the visit, Prof. Malicki visited IIMCB Zebrafish Core Facility, met with Prof. Jacek Kuźnicki (Director of IIMCB), Prof. Michał Witt and several lab leaders involved in zebrafish research. Prof. Malicki provided several very insightful practical comments, as well as advices regarding the optimization of current research efforts. Furthermore, IIMCB guest had several one on one discussions with the scientific staff hired in frame of the FishMed project.


DNA METHYLATION AND DEMETHYLATION

On September 14-18, 2013 Agnieszka Kolano PhD from Laboratory of Structural Biology was participating in Jacques Monod Conférence ‘’DNA methylation and demethylation’’ in Roscoff, France. Agnieszka Kolano was presenting a poster entitled ‘’The role of TET proteins in zebrafish’’. ”DNA methylation and demethylation” conference was organized by Pierre – Antoine Defossez from CNRS (Centre de la Recherche Scientifique, France). The aim of this conference was to discuss advances that have appeared in the past couple of years in the field of DNA methylation, with contributions from different fields: molecular biologists, cell biologists, developmentalists and chemists. The conference consisted of oral presentations (39 short talks) and 4 poster session (77 posters presented). During the conference there were 3 plenary lectures: Jean-Pierre Issa ”Epigenetic therapy using DNA methylation inhibitors”, Anjana Rao ”TET proteins and 5-methylcytosine oxidation” and Edith Heard ”X-chromosome inactivation: a paradigm of monoallelic gene expression and epigenetic regulation in mammals”. This conference ended with a discussion among all the scientists concerning where the field is going now.


8th EUROPEAN ZEBRAFISH MEETING

On July 9-13, 2013 delegation of six IIMCB researchers headed by Prof. Kuźnicki participated in the 8th European Zebrafish Meeting in Barcelona.  One of the aims of this event was to create an opportunity for people from different European countries and institutions to share and discuss the latest science in zebrafish. Participation in such an event gives the chance to share our experience and promote FishMed results. A competition notice for FishMed Research Group Leader in IIMCB was exposed during the general session. Furthermore, the conference was an opportunity to distribute brochures promoting the FishMed project and IIMCB.


THEMATIC WORKSHOP ON CAPACITY BUILDING
– STAIRWAY TO EXCELLENCE

On June 25, 2013 Marcin Ogonowski, FishMed Manager participated in the “Research Potential capitalization exercise: Thematic workshop on capacity building – Stairway to excellence” which was organized by European Commission in Brussels. It was an opportunity to promote FishMed project, discuss the project issues, show promotional materials about FishMed and IIMCB. During the workshop, there was a possibility to get to know about a good practices on capacity building in REGPOT projects (during presentations of project coordinators from different countries). Another important part of the meeting was sharing experiences on how FP7 and Structural Funds were used. What is more, future policies and funding opportunities (Horizon 2020, Structural Funds) were also discussed and presented by experts from DG Research&Innovation and DG Regional Policy from European Commission.


FUNCTIONAL ANATOMY OF CARDIOGENIC TRANSCRIPTION
FACTOR GATA4

On June 13-15, 2013 International Institute of Molecular and Cell Biology was visited by Dr. Branko Latinkić from Cardiff University, UK. During the first day of visit in IIMBC, Dr. Branko Latinkić held a seminar titled “Functional anatomy of cardiogenic transcription factor GATA4″. Dr. Latinkić is an expert on the GATA factors. The GATA family of transcription factors plays a key role in organogenesis. Although all members of the GATA family bind to the same DNA sequence, the effects of the GATA factors are organ-specific. The molecular basis for this specificity is ill-understood. Using Xenopus laevis, Xenopus tropicalis and Danio rerio as model animals, Dr. Latinkić has developed ex vivo explant assays to measure the cardiogenic potential of different GATA factors. Moreover, he has prepared chimeric GATA factors, which are molecularly almost identical to one GATA factor, yet functionally behave like another GATA factor. These chimeras are optimal tools to search for GATA interacting proteins in a planned collaboration. During his visit at IIMCB, Dr. Latinkić held discussions with group leaders at IIMCB (Prof. Jacek Kuznicki, Prof. Matthias Bochtler, Dr. hab. Marta Miaczynska, Dr. hab. Agnieszka Chacinska) as well as on the Ochota Campus (Dr. Agnieszka Dzikowska, Institute of Genetics of Warsaw University).


           5hmC IN ZEBRAFISH – THE ROLE OF TET ENZYMES

On June 7, 2013 during the Annual Report Session in Mierki, Agnieszka Kolano, PhD from Laboratory of Structural Biology delivered a presentation ,,5hmC in zebrafish – the role of TET enzymes’’, which was the first public lecture about The FishMed Project. Chromatin reprogramming is an essential part of reproduction and development. It involves the erasure of epigenetic information. In the case of DNA, reprogramming is associated with DNA demethylation. Active DNA demethylation requires conversion of 5methylcytosine (5mC) to 5hydroxymethylcytosine (5hmC) by Ten-Eleven-Translocation (TET) proteins. We want to investigate the role of 5hmC and the TET proteins in zebrafish to provide insight into their biological function in this organism.  If the roles are different from those in mammals, then the project will also shed light on the evolution of a major system of epigenetic reprogramming in vertebrates.


WIRE 2013 CONFERENCE
- WEEK OF INNOVATIVE REGIONS IN EUROPE

On June 5-7, 2013 Aleksandra Nałęcz-Tolak participated in the WIRE 2013 (Week of Innovative Regions in Europe) conference organized in Cork, Ireland. Aleksandra Nałęcz-Tolak took part in the plenary sessions, parallel sessions and in the exhibition. She was presenting a roll-up and brochures promoting the FishMed project, FishMed Centre and IIMCB.
One of the aims of the WIRE 2013 conference was to create an opportunity for people from different countries and institutions to discuss possible ways of creating and managing “smart innovations”. Participation in such an event gives the chance to exchange experience with innovative projects managers, scientists, local and European authorities. Furthermore, it facilitates benefiting from each other and promoting the FishMed Project and research on zebrafish models among scientific and non-scientific communities. The newly gained knowledge and established interpersonal contacts will lead to the increase of IIMCB’s research potential through sharing experience and promotion of the project results for commercialization purposes.

 

PROTEIN CRYSTALLOGRAPHY AT THE INTERFACE OF PHYSICS, CHEMISTRY AND BIOLOGY

On April 18-20, 2013 International Institute of Molecular and Cell Biology was visited by Prof. Robert Huber from Max-Planck Institute of Biochemistry Martinsried, Germany. During the visit in IIMBC on April 19, 2013 Prof. Huber delivered a seminar ‘’Protein crystallography at the interface of physics, chemistry and biology’’. Prof. Robert Huber, who was honored by a Nobel prize in Chemistry in 1988 is a pioneer of protein crystallography, and more recently also in structure based drug development. In the latter area, he has influenced the field both by academic projects (e.g. many of the proteosome inhibitors considered as alternatives for Bortezomib), but also by spin-off companies from his laboratory, particularly the Proteros company, which specializes in commercial service X-ray structure determination and small molecule screening. In his lecture, which was attended by a record number of participants, Prof. Huber covered all aspects of the process from basic X-ray structure determination to medical applications. Prof. Huber was hosted by Prof. Matthias Bochtler.

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